Blood Donation Machines and Devil Beggars are riskier, as they deplete health that is harder to replenish.
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However Eternal Hearts still act as an extra half a heart and become a full soul heart at the end of the floor making Prayer Card viable.
Maw of the Void can produce Black Hearts.
The same effect happens with the use of Judas' Shadow. Once this happens, however, you are no longer playing as ?, and therefore cannot get any of his achievements/unlocks.
The Poop - While not the most useful item, it can allow ? to cross small gaps by bombing the Poop from the opposite side, much like one would for Rocks.Enemies who deal full hearts of damage can be very dangerous in the early floors of the game.Sleeping on a bed will give ? three Soul Hearts.